Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.
Enobosarm, better known as as Ostarine or MK 2866, is a Selective Androgen Receptor Modulator (SARM) developed by GTx (GTx-024) to combat muscle wasting and osteoporosis.
SR9011 Basic Info
Molucelar Formula: C23H31ClN4O3S
Molucelar weight: 479.03524
Grade Standard:Medicine Grade
SR9011 Product Detail
The compound SR9009 works by binding to one of the body’s naturally occurring molecules, called Rev-Erbα. This molecule influences lipid and glucose metabolism in the liver, the production of fat-storing cells, and the response of macrophages (cells that remove dead or dying cells) during inflammation.
The study showed that mice lacking Rev-Erbα had decreased muscle metabolic activity and running capacity. However, Burris’ group demonstrated that activation of Rev-Erbα using Stenabolic led to increased metabolic activity in skeletal muscle in both culture and mice. The difference was a 50% increase in running capacity for mice treated with SR9009 – even when exercise was restricted.
Professor Burris explained that the study resulted in animals developing muscles just like an athlete who has been training, even when they haven’t. He believes that Rev-Erbα affects muscle cells through the creation of new mitochondria, and the removal of defective mitochondria via macrophages.
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