It acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist, and was the first of this class of drugs to be introduced clinically.
CJC-1295 with DAC (2mg)
(synonym CJC 1295 w/o dac-complex, modified form GRF 1-29 without DAC-complex) belongs to peptides hormones and contains 29 amino acids.
Ipamorelin (INN) (developmental code name NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue.
PT-141 (10mg) Basic Info
PT-141 (10mg) Product Detail
PT-141, commonly known as PT141 or Bremelanotide, is a synthetic heptapeptide analogue of the naturally occuring alpha-Melanocyte stimulating hormone (α-MSH) that is currently being studied for its numerous theoretical therapeutic applications. Alpha-MSH has potent influence over lipid metabolism, appetite, and sexual libido. PT-141 Bremelanotide, a metabolite of its predecessor Melanotan II, has the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH and a molecular weight of 1025.2 Dalton. In initial testing, Melanotan II did induce melanogenesis,but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Alpha-MSH activates certain melanocortin receptors in the process of exerting its effects. Resultantly, PT-141 has been shown in studies to exhibit libido-enhancing effects by activating melanocortin receptors. PT 141 has been researched extensively for its possible treatment of male sexual dysfunction (erectile dysfunction or impotence), female sexual dysfunction (sexual arousal disorder), hemorrhagic shock and reperfusion injury.
PT-141 in Men:
effective in a broad range of patients, including those with severe ED and those non-responsive to sildenafil,
effcacy in “at-home” studies is comparable to PDE-5 inhibitors up to 50% of ED patients were restored to a normal level of function coadministration with sildenafil shows superior efficacy
side effects include facial flushing, nausea, aftertaste and post-nasal drip
PT-141 in Women:
Palatin conducted a Phase 2A study in 18 premenopausal women with a diagnosis of female sexual dysfunction (FSD). Patients reported a significant
increase in sexual desire and in genital arousal after receiving PT-141, compared to placebo. Additionally, there was a correlation between sexual desire and genital arousal in patients receiving PT-141, an observation that further reinforces the potential importance of these reports.
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